Exercise Treatment for Major Depression: Maintenance of Therapeutic Benefit at 10 Months

  title={Exercise Treatment for Major Depression: Maintenance of Therapeutic Benefit at 10 Months},
  author={Michael A. Babyak and James A. Blumenthal and Steve Herman and Parinda Khatri and Murali Doraiswamy and Kathleen Moore and W. Edward Craighead and Teri T. Baldewicz and K. Ranga Krishnan},
  journal={Psychosomatic Medicine},
Objective The purpose of this study was to assess the status of 156 adult volunteers with major depressive disorder (MDD) 6 months after completion of a study in which they were randomly assigned to a 4-month course of aerobic e-ercise, sertraline therapy, or a combination of e-ercise and sertraline. Methods The presence and severity of depression were assessed by clinical interview using the Diagnostic Interview Schedule and the Hamilton Rating Scale for Depression (HRSD) and by self-report… 

Exercise and Pharmacotherapy in the Treatment of Major Depressive Disorder

The efficacy of exercise in patients seems generally comparable with patients receiving antidepressant medication and both tend to be better than the placebo in patients with MDD.

Exercise and Pharmacotherapy in Patients With Major Depression: One-Year Follow-Up of the SMILE Study

The effects of aerobic exercise on MDD remission seem to be similar to sertraline after 4 months of treatment; exercise during the follow-up period seems to extend the short-term benefits of exercise and may augment the benefits of antidepressant use.

The Effects of a Group Exercise Intervention in the Adjunctive Treatment of Clinical Depression

It was concluded that social interaction may have contributed to the positive findings concerning symptoms of depression.

Assessing the additional impact of fitness training in depressed psychiatric patients receiving multifaceted treatment: a replicated single-subject design

Adding fitness training to the treatment of clinical depression does not systematically lead to changes in self-reported feelings of depression on top of benefits that may be due to other treatments.

Exercise Leads to Better Clinical Outcomes in Those Receiving Medication Plus Cognitive Behavioral Therapy for Major Depressive Disorder

Evidence that exercise as an add-on to conventional antidepressant therapies improved the efficacy of standard treatment interventions is provided and plasma BDNF levels and sleep quality appear to be good indicators of treatment response and potential biomarkers associated with the clinical recovery of MDD.

Mental health and quality of life during weight loss in females with clinically severe obesity: a randomized clinical trial.

Exercise training confers an additional benefit to energy restriction in the absence of additional weight loss at 12 months for health-related quality of life, depressive symptoms, and state and trait anxiety scores when compared to energy restricted only.

The effects of physical activity in the acute treatment of bipolar disorder: a pilot study.

Six-month and one-year followup of 23 weeks of aerobic exercise for individuals with fibromyalgia.

Exercise can improve physical function, mood, symptom severity, and aspects of self efficacy for at least 12 months following 23 weeks of supervised aerobic exercise.

Effects of exercise training on older patients with major depression.

After 16 weeks of treatment exercise was equally effective in reducing depression among patients with MDD, and an exercise training program may be considered an alternative to antidepressants for treatment of depression in older persons.

Effects of Aerobic Exercise Versus Stress Management Treatment in Fibromyalgia

AE was the overall most effective treatment, despite being subject to the most sceptical patient attitude prior to the study, and there were no obvious group differences in symptom severity.

Double-blind, multicenter comparison of sertraline and amitriptyline in elderly depressed patients.

Sertraline was associated with a statistically lower frequency of somnolence, dry mouth, constipation, ataxia, and pain and a higher frequency of nausea, anorexia, diarrhea/loose stools, and insomnia; thus, anticholinergic effects were less common and gastrointestinal effects were more common with sertralines than with amitriptyline.

MRI-defined vascular depression.

Bivariate analyses and a fully adjusted logistic regression model revealed that older age, late age at onset, and nonpsychotic subtype occurred more often in patients with vascular depression than in those with nonvascular depression.

Physical activity and depressive symptoms: the NHANES I Epidemiologic Follow-up Study.

Findings are the first indication from a prospective study of a large community sample that physical inactivity may be a risk factor for depressive symptoms.

A structured interview guide for the Hamilton Depression Rating Scale.

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A test-retest reliability study conducted on a series of psychiatric inpatients demonstrated that the use of the SIGH-D results in a substantially improved level of agreement for most of the HDRS items.

The effect of exercise on depressive symptoms in the moderately depressed elderly.

It is indicated that, at least in the short term, exercise has a broader effect compared with control conditions in reducing depressive symptoms in the moderately depressed elderly.

Conceptualization and rationale for consensus definitions of terms in major depressive disorder. Remission, recovery, relapse, and recurrence.

It is concluded that research on depressive illness would be well served by greater consistency in the definition change points in the course of illness, and proposes an internally consistent, empirically defined conceptual scheme for the terms remission, recovery, relapse, and recurrence.

Psychological Changes Accompany Aerobic Exercise in Healthy Middle‐Aged Adults

Results document the potential utility of regular aerobic exercise in promoting psychological health in normal adults and show that the exercisers exhibited less state and trait anxiety, less tension, depression, and fatigue, and more vigor than the controls.