Exercise Training Prevents Oxidative Stress and Ubiquitin-Proteasome System Overactivity and Reverse Skeletal Muscle Atrophy in Heart Failure

@inproceedings{Cunha2012ExerciseTP,
  title={Exercise Training Prevents Oxidative Stress and Ubiquitin-Proteasome System Overactivity and Reverse Skeletal Muscle Atrophy in Heart Failure},
  author={Telma F. Cunha and Aline Villa Nova Bacurau and Jos{\'e} Bianco Nascimento Moreira and Nathalie A. Paix{\~a}o and Juliane Cruz Campos and Julio C B Ferreira and Marcelo Larciprete Leal and Carlos Eduardo Negrāo and Anselmo Sigari Moriscot and Ulrik Wisl\off and Patr{\'i}cia C Brum},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Heart failure (HF) is known to lead to skeletal muscle atrophy and dysfunction. However, intracellular mechanisms underlying HF-induced myopathy are not fully understood. We hypothesized that HF would increase oxidative stress and ubiquitin-proteasome system (UPS) activation in skeletal muscle of sympathetic hyperactivity mouse model. We also tested the hypothesis that aerobic exercise training (AET) would reestablish UPS activation in mice and human HF. METHODS/PRINCIPAL FINDINGS… CONTINUE READING
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