Exercise Training Preserves Ischemic Preconditioning in Aged Rat Hearts by Restoring the Myocardial Polyamine Pool

@inproceedings{Wang2014ExerciseTP,
  title={Exercise Training Preserves Ischemic Preconditioning in Aged Rat Hearts by Restoring the Myocardial Polyamine Pool},
  author={Weiwei Wang and Hao Zhang and Guo Xue and Li Zhang and Weihua Zhang and Li-na Wang and Fanghao Lu and Hongzhu Li and Shuzhi Bai and Yan Lin and Y B Lou and Changqing Xu and Yajun Zhao},
  booktitle={Oxidative medicine and cellular longevity},
  year={2014}
}
BACKGROUND Ischemic preconditioning (IPC) strongly protects against myocardial ischemia reperfusion (IR) injury. However, IPC protection is ineffective in aged hearts. Exercise training reduces the incidence of age-related cardiovascular disease and upregulates the ornithine decarboxylase (ODC)/polyamine pathway. The aim of this study was to investigate whether exercise can reestablish IPC protection in aged hearts and whether IPC protection is linked to restoration of the cardiac polyamine… CONTINUE READING

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