Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue

  title={Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue},
  author={Marissa J. Schafer and Thomas A. White and Glenda L. Evans and Jason M. Tonne and Grace C. Verzosa and Michael B. Stout and Daniel L. Mazula and Allyson K Palmer and Darren J. Baker and Michael D Jensen and Michael S. Torbenson and Jordan D. Miller and Yasuhiro Ikeda and Tamara T. Tchkonia and Jan M van Deursen and James l. Kirkland and Nathan K. Lebrasseur},
Considerable evidence implicates cellular senescence in the biology of aging and chronic disease. Diet and exercise are determinants of healthy aging; however, the extent to which they affect the behavior and accretion of senescent cells within distinct tissues is not clear. Here we tested the hypothesis that exercise prevents premature senescent cell accumulation and systemic metabolic dysfunction induced by a fast-food diet (FFD). Using transgenic mice that express EGFP in response to… CONTINUE READING
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