Exercise-Induced Genomic and Transcriptomic Changes in Heart Failure.

@article{Bondar2020ExerciseInducedGA,
  title={Exercise-Induced Genomic and Transcriptomic Changes in Heart Failure.},
  author={G. Bondar and T. Bao and M. Kurani and E. Oh and K. Patel and K. Shah and Scott D. Nelson and S. Savvidou and S. Kupiec-Weglinsky and G. Fadly and E. Higuchi and I. Silacheva and N. Lapierre and Z. Li and K. Genewick and S. Yu and T. Grogan and D. Elashoff and W. Wang and P. Ping and M. Rossetti and E. Reed and Xinmin Li and M. Deng},
  journal={The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation},
  year={2020},
  volume={39 4S},
  pages={
          S471
        }
}
  • G. Bondar, T. Bao, +21 authors M. Deng
  • Published 2020
  • Medicine
  • The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
PURPOSE Cardiorespiratory test (CPX) directly measures cardiorespiratory fitness (CF). CF refers to the ability to supply oxygen to skeletal muscles during sustained exercise and is measured by peak oxygen uptake (VO2) per kg/min body weight. We postulate that impaired CF is associated with pro-inflammatory mechanisms in heart failure (HF). CPX-induced cell free mitochondria DNA (cf-mtDNA) release mediates a pro-inflammatory pattern in HF patients evaluated for heart transplantation. We… Expand