Exercise, caloric restriction, and systemic oxidative stress.

  title={Exercise, caloric restriction, and systemic oxidative stress.},
  author={Pietro Renato Galassetti and Dan Nemet and Andria Pescatello and Christie M Rose-Gottron and Jennifer K Larson and Dan M. Cooper},
  journal={Journal of investigative medicine : the official publication of the American Federation for Clinical Research},
  volume={54 2},
BACKGROUND In humans, the main sources of reactive oxygen species (ROS), the molecules causing oxidative stress, are mitochondrial superoxide ions and neutrophil-derived oxidative radicals. Circulating antioxidants contribute to the protection against oxidative stress. Although the formation of ROS and secretion of antioxidants are independently regulated by exercise and diet, little is known about their combined effect. We hypothesized that relatively brief, intense exercise training may… CONTINUE READING


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