Exercise, alveolar macrophage function, and susceptibility to respiratory infection.

@article{Davis1997ExerciseAM,
  title={Exercise, alveolar macrophage function, and susceptibility to respiratory infection.},
  author={J. Mark Davis and Marian L Kohut and Lisa H. Colbert and David Arthur Jackson and Abdul Ghaffar and Eugene P. Mayer},
  journal={Journal of applied physiology},
  year={1997},
  volume={83 5},
  pages={
          1461-6
        }
}
The effects of exercise on susceptibility to respiratory infection were determined by using a murine model of intranasal challenge with herpes simplex type 1 virus (HSV-1). Two doses of treadmill exercise were assessed: moderate short-term (30 min) exercise and prolonged strenuous exercise to voluntary fatigue (2.5-3.5 h). Morbidity and mortality among exercised and control mice were compared after intranasal challenge with HSV-1. We also assessed the ability of alveolar macrophages to restrict… 
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Exercise stress increases susceptibility to influenza infection

Gender differences in viral infection after repeated exercise stress.

Results suggest that although males and females have similar morbidity rates after infection and exercise stress, females recover to a greater extent and are ultimately better protected from death.

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Results indicate that intact female mice are better protected from the lethal effects of HSV-1 infection and that exercise stress had a similar negative impact in all groups, indicating that other ovarian factors, alone or in combination with estrogen, are responsible for the protective effects in females.

Moderate exercise early after influenza virus infection reduces the Th1 inflammatory response in lungs of mice.

Moderate exercise when applied early after infection shifts the immune response away from a Th1 profile in mice infected with influenza virus, suggesting this exercise-induced shift in immune response may be responsible for improved survival after influenza virus infection.

Prolonged exercise suppresses antigen-specific cytokine response to upper respiratory infection.

It is suggested that fatiguing exercise may alter the kinetics of antigen-specific cytokine production, which is associated with an increased susceptibility to infection and natural killer cell cytotoxicity.

Moderate exercise protects mice from death due to influenza virus

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A positive effect of both moderate exercise and oat beta-glucan on immune function is confirmed, but only moderate exercise was associated with a significant reduction in the risk of upper respiratory tract infection in this model.
...

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