Exercise, Learned Helplessness, and the Stress-Resistant Brain
@article{Greenwood2008ExerciseLH, title={Exercise, Learned Helplessness, and the Stress-Resistant Brain}, author={Benjamin N. Greenwood and Monika Fleshner}, journal={NeuroMolecular Medicine}, year={2008}, volume={10}, pages={81-98} }
Exercise can prevent the development of stress-related mood disorders, such as depression and anxiety. The underlying neurobiological mechanisms of this effect, however, remain unknown. Recently, researchers have used animal models to begin to elucidate the potential mechanisms underlying the protective effects of physical activity. Using the behavioral consequences of uncontrollable stress or “learned helplessness” as an animal analog of depression- and anxiety-like behaviors in rats, we are…
156 Citations
Exercise offers anxiolytic potential: A role for stress and brain noradrenergic-galaninergic mechanisms
- Psychology, BiologyNeuroscience & Biobehavioral Reviews
- 2012
Trophic Mechanisms for Exercise-Induced Stress Resilience: Potential Role of Interactions between BDNF and Galanin
- Psychology, BiologyFront. Psychiatry
- 2014
This paper will provide an overview of trophic mechanisms responsible for the enhancement of resilience by voluntary exercise with an emphasis on brain-derived neurotrophic factor, galanin, and interactions between these two Trophic factors.
Voluntary exercise and depression-like behavior in rodents: are we running in the right direction?
- Psychology, BiologyJournal of molecular endocrinology
- 2018
A review of several neurotransmitter systems that are putative mediators of the beneficial effects of exercise training on mental health, and a review of recent rodent studies that utilized voluntary wheel running to promote the understanding of exerciseTraining-induced central adaptations.
Voluntary exercise and depression-like behavior in rodents : are we running in the right direction ?
- Psychology, Biology
- 2018
A review of several neurotransmitter systems that are putative mediators of the beneficial effects of exercise training on mental health, and a review of recent rodent studies that utilized voluntary wheel running to promote the understanding of exerciseTraining-induced central adaptations.
Voluntary exercise and depression-like behavior in rodents : are we running in the right direction ?
- Psychology, Biology
- 2018
A review of several neurotransmitter systems that are putative mediators of the beneficial effects of exercise training on mental health, and a review of recent rodent studies that utilized voluntary wheel running to promote the understanding of exerciseTraining-induced central adaptations.
Voluntary exercise and depression-like behavior in rodents : are we running in the right direction ?
- Psychology, Biology
- 2018
A review of several neurotransmitter systems that are putative mediators of the beneficial effects of exercise training on mental health, and a review of recent rodent studies that utilized voluntary wheel running to promote the understanding of exerciseTraining-induced central adaptations.
Voluntary exercise and depression-like behavior in rodents : are we running in the right direction ?
- Psychology, Biology
- 2018
A review of several neurotransmitter systems that are putative mediators of the beneficial effects of exercise training on mental health, and a review of recent rodent studies that utilized voluntary wheel running to promote the understanding of exerciseTraining-induced central adaptations.
Voluntary exercise and depression-like behavior in rodents : are we running in the right direction ?
- Psychology, Biology
- 2018
A review of several neurotransmitter systems that are putative mediators of the beneficial effects of exercise training on mental health, and a review of recent rodent studies that utilized voluntary wheel running to promote the understanding of exerciseTraining-induced central adaptations.
Voluntary exercise and depression-like behavior in rodents : are we running in the right direction ?
- Psychology, Biology
- 2018
A review of several neurotransmitter systems that are putative mediators of the beneficial effects of exercise training on mental health, and a review of recent rodent studies that utilized voluntary wheel running to promote the understanding of exerciseTraining-induced central adaptations.
Voluntary exercise and depression-like behavior in rodents : are we running in the right direction ?
- Psychology, Biology
- 2018
A review of several neurotransmitter systems that are putative mediators of the beneficial effects of exercise training on mental health, and a review of recent rodent studies that utilized voluntary wheel running to promote the understanding of exerciseTraining-induced central adaptations.
References
SHOWING 1-10 OF 252 REFERENCES
Beneficial effects of exercise and its molecular mechanisms on depression in rats
- Biology, PsychologyBehavioural Brain Research
- 2006
Learned helplessness and animal models of depression
- PsychologyProgress in Neuro-Psychopharmacology and Biological Psychiatry
- 1984
Learned helplessness is independent of levels of brain-derived neurotrophic factor in the hippocampus
- Biology, PsychologyNeuroscience
- 2007
Brain monoamines, exercise, and behavioral stress: animal models.
- Biology, PsychologyMedicine and science in sports and exercise
- 1997
It is found that chronic activity wheel running increased NE levels in the pons medulla at rest and protected against NE depletion in locus coeruleus cell bodies after footshock; the concomitant reduction in escape-latency was consistent with an antidepressant effect.
Posttraumatic Stress and Depression
- Biology, PsychologyAnnals of the New York Academy of Sciences
- 1997
5-HT may be the key neurotransmitter involved in the development and maintenance of LH in mPFC, and a link from the mP FC via the entorhinal cortex (GABA locus) to the hippocampus is hypothesized, essential to homeostasis and to prevention of deleterious stress effects.
Exposure to the stressor environment prevents the temporal dissipation of behavioral depression/learned helplessness
- PsychologyBiological Psychiatry
- 2001
A Neurotrophic Model for Stress-Related Mood Disorders
- Psychology, BiologyBiological Psychiatry
- 2006
Stressor controllability and learned helplessness: The roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor
- Psychology, BiologyNeuroscience & Biobehavioral Reviews
- 2005
Behavioral depression produced by an uncontrollable stressor: Relationship to norepinephrine, dopamine, and serotonin levels in various regions of rat brain
- Psychology, BiologyBrain Research Reviews
- 1981
The consequences of uncontrollable stress are sensitive to duration of prior wheel running
- Biology, PsychologyBrain Research
- 2005