Exendin-4 relieves the inhibitory effects of high glucose on the proliferation and osteoblastic differentiation of periodontal ligament stem cells.

@article{Guo2018Exendin4RT,
  title={Exendin-4 relieves the inhibitory effects of high glucose on the proliferation and osteoblastic differentiation of periodontal ligament stem cells.},
  author={Zijun Guo and Rui Chen and Fujun Zhang and Ming Ding and Ping Wang},
  journal={Archives of oral biology},
  year={2018},
  volume={91},
  pages={
          9-16
        }
}
BACKGROUND With the impaired regenerative potential in patients with diabetes mellitus (DM), Periodontal ligament stem cells (PDLSCs) are regarded as an attractive source of stem cells for periodontal cytotherapy. Recent studies have shown that Exendin-4 (Ex-4) exerts cell-protective effects and bone remodeling ability on many types of cells. The aim of this study was to investigate whether Ex-4 alleviates the inhibition of high glucose on the proliferation and osteogenic differentiation of… CONTINUE READING