Exendin-4 potently decreases ghrelin levels in fasting rats.

@article{PrezTilve2007Exendin4PD,
  title={Exendin-4 potently decreases ghrelin levels in fasting rats.},
  author={Diego P{\'e}rez-Tilve and Lucas C Gonz{\'a}lez-Mat{\'i}as and Mayte {\'A}lvarez-Crespo and Roberto Leiras and S. {\'O}scar Tovar and Carlos Di{\'e}guez and Federico Mallo},
  journal={Diabetes},
  year={2007},
  volume={56 1},
  pages={143-51}
}
Ghrelin is a potent orexigenic and adipogenic hormone that strongly influences fat deposition and the generation of hunger in obesity. Indeed, hyperghrelinemia appears to promote an increase in food intake as seen in Prader-Willi Syndrome (PWS). Exendin (Ex)-4 is an agonist of the glucagon-like peptide (GLP)-1 receptor (GLP-1r) that has anorexigenic and fat-reducing properties. Here, we report that Ex-4 reduces the levels of ghrelin by up to 74% in fasted rats. These effects are dose dependent… CONTINUE READING

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Kamegai EXENDIN-4 INHIBITS GHRELIN

  • Y Shuto, T Shibasaki, A Otagiri, H Kuriyama, H Ohata, H Tamura
  • DIABETES, VOL
  • 2007
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