Exendin-4 and sitagliptin protect kidney from ischemia-reperfusion injury through suppressing oxidative stress and inflammatory reaction

@inproceedings{Chen2013Exendin4AS,
  title={Exendin-4 and sitagliptin protect kidney from ischemia-reperfusion injury through suppressing oxidative stress and inflammatory reaction},
  author={Yen-ta Chen and Tzu-hsien Tsai and Chih-chau Yang and Cheuk-Kwan Sun and Li-Teh Chang and Hung-Hwa Chen and Chien-Hung Chang and Pei-Hsun Sung and Yen-yi Zhen and Steve Leu and H. B. Chang and Yung-Lung Chen and Hon-Kan Yip},
  booktitle={Journal of Translational Medicine},
  year={2013}
}
BackgroundThis study tested the hypothesis that exendin-4 and sitagliptin can effectively protect kidney from acute ischemia-reperfusion (IR) injury.MethodsAdult SD-rats (n = 48) equally divided into group 1 (sham control), group 2 (IR injury), group 3 [IR + sitagliptin 600 mg/kg at post-IR 1, 24, 48 hr)], and group 4 [IR + exendin-4 10 μm/kg at 1 hr after procedure] were sacrificed after 24 and 72 hrs (n = 6 at each time from each group) following clamping of bilateral renal pedicles for 60… CONTINUE READING
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