Exendin-4, a glucagon-like peptide-1 receptor agonist, reduces Alzheimer disease-associated tau hyperphosphorylation in the hippocampus of rats with type 2 diabetes.

@article{Xu2015Exendin4AG,
  title={Exendin-4, a glucagon-like peptide-1 receptor agonist, reduces Alzheimer disease-associated tau hyperphosphorylation in the hippocampus of rats with type 2 diabetes.},
  author={Weijie Xu and Yan Yang and Gang Yuan and Wenjun Zhu and Delin Ma and Shuhong Hu},
  journal={Journal of investigative medicine : the official publication of the American Federation for Clinical Research},
  year={2015},
  volume={63 2},
  pages={
          267-72
        }
}
BACKGROUND Impaired insulin signaling pathway in the brain in type 2 diabetes (T2D) is a risk factor for Alzheimer disease (AD). Glucagon-like peptide-1 (GLP-1) and its receptor agonist are widely used for treatment of T2D. Here we studied whether the effects of exendin-4 (EX-4), a long-lasting GLP-1 receptor agonist, could reduce the risk of AD in T2D. MATERIALS AND METHODS Type 2 diabetes rats were injected with EX-4 for 28 consecutive days. Blood glucose and insulin levels, as well as GLP… CONTINUE READING
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