Exendin-4, a glucagon-like peptide-1 receptor agonist, attenuates neointimal hyperplasia after vascular injury.

@article{Hirata2013Exendin4AG,
  title={Exendin-4, a glucagon-like peptide-1 receptor agonist, attenuates neointimal hyperplasia after vascular injury.},
  author={Yoichiro Hirata and Hirotsugu Kurobe and Chika Nishio and Kimie Tanaka and Daiju Fukuda and Etsuko Uematsu and Sachiko Nishimoto and Takeshi Soeki and Nagakatsu Harada and Hiroshi Sakaue and Tetsuya Kitagawa and Michio Shimabukuro and Yutaka Nakaya and Masataka Sata},
  journal={European journal of pharmacology},
  year={2013},
  volume={699 1-3},
  pages={
          106-11
        }
}
Exendin-4 is a glucagon-like peptide-1 receptor agonist that has been used as a drug for treatment of type 2 diabetes. To investigate the effect of exendin-4 on the cardiovascular system, we investigated the impact of exendin-4 on neointimal hyperplasia of the femoral artery after vascular injury. We performed wire-mediated endovascular injury in C57BL/6 mice, followed by administration of exendin-4 24 nmol/kg/day via infusion pump. Four weeks after the injury, exendin-4 treatment significantly… CONTINUE READING

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