Exendin(9-39)amide is an antagonist of glucagon-like peptide-1(7-36)amide in humans.

  title={Exendin(9-39)amide is an antagonist of glucagon-like peptide-1(7-36)amide in humans.},
  author={J{\"o}rg R. J. Schirra and Kerstin Sturm and Pernille Leicht and Rudolf Arnold and Burkhard G{\"o}ke and Martin Katschinski},
  journal={The Journal of clinical investigation},
  volume={101 7},
The gastrointestinal hormone, glucagon-like peptide-1(7-36)amide (GLP-1) is released after a meal. The potency of synthetic GLP-1 in stimulating insulin secretion and in inhibiting glucagon secretion indicates the putative physiological function of GLP-1. In vitro, the nonmammalian peptide, exendin(9-39)amide [ex(9-39)NH2], is a specific and competitive antagonist of GLP-1. This in vivo study examined the efficacy of ex(9-39)NH2 as an antagonist of exogenous GLP-1 and the physiological role of… CONTINUE READING


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