Exendin(9-39)amide is an antagonist of glucagon-like peptide-1(7-36)amide in humans.

@article{Schirra1998Exendin939amideIA,
  title={Exendin(9-39)amide is an antagonist of glucagon-like peptide-1(7-36)amide in humans.},
  author={J{\"o}rg R. J. Schirra and Kerstin Sturm and Pernille Leicht and Rudolf Arnold and Burkhard G{\"o}ke and Martin Katschinski},
  journal={The Journal of clinical investigation},
  year={1998},
  volume={101 7},
  pages={1421-30}
}
The gastrointestinal hormone, glucagon-like peptide-1(7-36)amide (GLP-1) is released after a meal. The potency of synthetic GLP-1 in stimulating insulin secretion and in inhibiting glucagon secretion indicates the putative physiological function of GLP-1. In vitro, the nonmammalian peptide, exendin(9-39)amide [ex(9-39)NH2], is a specific and competitive antagonist of GLP-1. This in vivo study examined the efficacy of ex(9-39)NH2 as an antagonist of exogenous GLP-1 and the physiological role of… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 50 references

Glucagon-like peptide I and glucose-dependent insulinotropic polypeptide stimulate Ca21-induced secretion in rat a-cells by a protein kinase A-mediated mechanism

Ding, W.-G, +3 authors J. Gromada
Diabetes . • 1997
View 12 Excerpts
Highly Influenced

Glucagon-like peptide-1 is a physiologic regulator of food intake in humans. Gastroenterology

Gutzwiller, J.-P, +7 authors C. Beglinger
1997
View 12 Excerpts
Highly Influenced

A role for glucagon-like peptide-1 in the central regulation of feeding

M. D. Turton, D. Oshea, +7 authors P. D. Lambert
Nature . • 1996
View 12 Excerpts
Highly Influenced

Effects of GLP-1 on human antro-pyloro-duodenal motility

J. Schirra, U. Wank, P. Houck, B. Göke, M. Katschinski
Gastroenterology. 110:A1116 • 1996
View 12 Excerpts
Highly Influenced

Glucagon and other proglucagonderived peptides. In Gut Peptides: Biochemistry and Physiology

J. J. Holst, C. Ørskov
J.H. Walsh and G.J. Dockray, • 1996
View 13 Excerpts
Highly Influenced

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