Exenatide improves both hepatic and adipose tissue insulin resistance: A dynamic positron emission tomography study.

@article{Gastaldelli2016ExenatideIB,
  title={Exenatide improves both hepatic and adipose tissue insulin resistance: A dynamic positron emission tomography study.},
  author={Amalia Gastaldelli and Melania Gaggini and Giuseppe Daniele and Demetrio Ciociaro and Eugenio Cersosimo and Devjit Tripathy and Curtis L. Triplitt and Peter M. Fox and Nicolas Musi and Ralph A DeFronzo and Patricia Iozzo},
  journal={Hepatology},
  year={2016},
  volume={64 6},
  pages={
          2028-2037
        }
}
Glucagon-like peptide 1 (GLP-1) receptor agonists (GLP-1-RAs) act on multiple tissues, in addition to the pancreas. Recent studies suggest that GLP-1-RAs act on liver and adipose tissue to reduce insulin resistance (IR). Thus, we evaluated the acute effects of exenatide (EX) on hepatic (Hep-IR) and adipose (Adipo-IR) insulin resistance and glucose uptake. Fifteen male subjects (age = 56 ± 8 years; body mass index = 29 ± 1 kg/m2 ; A1c = 5.7 ± 0.1%) were studied on two occasions, with a double… CONTINUE READING

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