Executive dysfunction in substance dependent individuals during drug use and abstinence: An examination of the behavioral, cognitive and emotional correlates of addiction

@article{VerdejoGarca2006ExecutiveDI,
  title={Executive dysfunction in substance dependent individuals during drug use and abstinence: An examination of the behavioral, cognitive and emotional correlates of addiction},
  author={Antonio Verdejo-Garc{\'i}a and Antoine Bechara and Emily C. Recknor and Miguel P{\'e}rez-Garc{\'i}a},
  journal={Journal of the International Neuropsychological Society},
  year={2006},
  volume={12},
  pages={405 - 415}
}
Increasing evidence indicates that substance-dependent individuals (SDI) are impaired in executive control tasks relying on different systems within the prefrontal cortex (PFC). Three different functional systems have been described: the dorsolateral prefrontal cortex (DLPC), orbitofrontal cortex (OFC), and anterior cingulate cortex (ACC) circuits. Dysfunction within each PFC system is associated with different behavioral, cognitive, and emotional abnormalities. Few studies have conducted an… Expand
Executive control deficits in substance-dependent individuals: A comparison of alcohol, cocaine, and methamphetamine and of men and women
TLDR
Decision making was significantly more impaired in women addicted to cocaine or methamphetamine than in men addicted to these drugs, suggesting that drug of choice and sex have different effects on executive functioning, which may help tailor intervention. Expand
Strategic self-regulation, decision-making and emotion processing in poly-substance abusers in their first year of abstinence.
TLDR
The results suggest that the evaluation of emotion, self-regulation and decision-making contributes greatly to the characterization of the persistent deficits exhibited by ISD during prolonged abstinence, and found significant correlations between the different measures linked to OFC functioning. Expand
Differential Improvement of Executive Functions During Abstinence in Cocaine-Dependent Patients: A Longitudinal Study
TLDR
Results suggest that executive improvement and treatment adherence in cocaine abusers in abstinence is related to intrinsic cognitive characteristics of patients. Expand
Frontal behavioral and emotional symptoms in Spanish individuals with acquired brain injury and substance use disorders.
TLDR
The Spanish version of the FrSBe is a useful instrument for the detection of behavioral problems associated with frontal systems dysfunction in two clinical samples of Spanish-speakers. Expand
Executive Cognitive Dysfunction and ADHD in Cocaine Dependence: Searching for a Common Cognitive Endophenotype for Addictive Disorders
TLDR
CDI’s+ ADHD presented more pronounced executive alterations than CDI and CDI exhibited poorer cognitive functioning than controls, suggesting that pre-existing ADHD symptoms may have a significant negative impact on executive dysfunction in CDI. Expand
Executive functioning and substance use disorders
Abstract Executive functioning has been extensively studied over the past six decades and can be defined as a dynamic multifaceted construct that includes different but intercorrelated processes thatExpand
Cognitive deficits in methamphetamine addiction: Independent contributions of dependence and intelligence.
TLDR
The need to target disinhibition and impulsive decision-making as part of methamphetamine dependence treatment, while buffering the impact of IQ on memory systems is suggested. Expand
Diversities of behavioral traits and neuropsychological function in different substance addiction
TLDR
Individuals with different substance dependence have distinct behavioral traits for developing addicted behaviors and had variant deficits of neuropsychological function. Expand
Assessment of Executive Function in Patients With Substance Use Disorder: A Comparison of Inventory- and Performance-Based Assessment.
TLDR
The BRIEF-A inventory was the most sensitive measure of executive function in patients with substance use disorder, followed by measures of cold executive function, and should be considered as an integral part of the clinical routine when assessing patients with SUD. Expand
Childhood physical neglect associated with executive functions impairments in crack cocaine-dependent women.
TLDR
CPN is associated with cognitive impairments in crack cocaine-dependent women specifically regarding EFs and working memory tasks and a multivariate analysis of covariance indicated significant group differences in EFs. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 76 REFERENCES
Relationship between drug use and prefrontal‐associated traits
TLDR
This study further supports a relationship between prefrontal dysfunction and drug use in normal individuals, convergently with other methodologies for studying addiction. Expand
Prefrontal cortical dysfunction in abstinent cocaine abusers.
TLDR
Disruption of ECF in substance abusers could interfere with attempts to stop drug use and undermine treatment, and these findings have applicability beyond the neurobiology of addiction. Expand
Decision-making deficits, linked to a dysfunctional ventromedial prefrontal cortex, revealed in alcohol and stimulant abusers
TLDR
The hypothesis that impairment in decision-making linked to a dysfunctional VM cortex is associated with at least a sub-group of substance dependent individuals (SD) is supported. Expand
Cocaine dependence and attention switching within and between verbal and visuospatial working memory
TLDR
The results reveal that addiction may be accompanied by specific rather than ubiquitous hypoactivation in prefrontal and subcortical areas and suggest a compromised ability in users to control their attention to their thoughts as might be particularly relevant when required to switch away from drug‐related thoughts, and thus the dysfunction in attention switching may contribute to the maintenance of addiction. Expand
Profiles of Cognitive Dysfunction in Chronic Amphetamine and Heroin Abusers
TLDR
The results indicate that chronic drug use may lead to distinct patterns of cognitive impairment that may be associated with dysfunction of different components of cortico-striatal circuitry. Expand
Abnormal frontal activations related to decision-making in current and former amphetamine and opiate dependent individuals
TLDR
A disturbance in the mediation by the prefrontal cortex of a risky decision-making task associated with amphetamine and opiate abuse was observed in a group of former drug users who had been abstinent for at least 1 year. Expand
Neuropsychological functioning in drug abusers.
TLDR
Correlations between neuropsychological performance and length of abstinence from drug use showed the ETOH group to have made the greatest amount of improvement on individual measures and domains, and the COC group showed the least amount of Improvement. Expand
Clinical Implications and Methodological Challenges in the Study of the Neuropsychological Correlates of Cannabis, Stimulant, and Opioid Abuse
TLDR
The aim of this review is to summarize the main neuropsychological impairments shown by classic studies, as well as these new discoveries in executive functioning and highlight the convenience of intervening in those functions most relevant to the abusers' persistence in consumption and risk of relapse. Expand
Frontal Systems Behavior Scale in schizophrenia: relationships with psychiatric symptomatology, cognition and adaptive function
TLDR
Results support the use of the FrSBe to characterize goal-directed behavior in schizophrenia patients by finding good internal consistency and test-retest reliability and differential relationships for apathy and disinhibition. Expand
Differential effects of cocaine and cocaine alcohol on neurocognitive performance
TLDR
The concomitant use of cocaine and alcohol may have additive negative effects on the brain as compared to the use of only one of these two substances. Expand
...
1
2
3
4
5
...