Executive control of working memory in schizophrenia

  title={Executive control of working memory in schizophrenia},
  author={Joanne Oram and Gina Malke Geffen and Laurence Basil Geffen and David John Kavanagh and John J. McGrath},
  journal={Psychiatry Research},
There is considerable evidence that working memory impairment is a common feature of schizophrenia. The present study assessed working memory and executive function in 54 participants with schizophrenia, and a group of 54 normal controls matched to the patients on age, gender and estimated premorbid IQ, using traditional and newer measures of executive function and two dual tasks-Telephone Search with Counting and the Memory Span and Tracking Task. Results indicated that participants with… 
Automatization and working memory capacity in schizophrenia
The findings suggest that inefficient WM function and reduced capacity in schizophrenia may be related to an inability to process information requiring frequent updating, and this was evident when processing continuously changing information.
Short-term memory activity in schizophrenic patients
Introduction: Recent research findings about schizophrenia have shown that this disorder was associated with considerable cognitive and perceptual deficits, specifically in areas of attention and
Dual Tasking and Working Memory in Alcoholism: Relation to Frontocerebellar Circuitry
The brain–behavior correlations suggest that alcoholics and controls relied on the integrity of certain nodes of corticocerebellar systems to perform these verbal and spatial working memory tasks, but that the specific pattern of relationships differed by group.
Working memory impairments in first-episode psychosis and chronic schizophrenia
Differences of working memory functions between 33 first-episode and 29 chronic schizophrenic patients, as well as 64 healthy controls, are examined, finding reaction time was slower and accuracy was worse in both patient groups than in controls.
Attentional control in patients with temporal lobe epilepsy.
It is found that impairments in attentional control in TLE tend to be selective, and sustained attention is less compromised and the capacity to allocate cognitive resources appears to be normal in patients with TLE.
Working memory and multi-tasking in paranoid schizophrenia with and without comorbid substance use disorder.
The present study indicates severe working memory and multi-tasking deficits in schizophrenia which are, however, not exacerbated by comorbid addiction.
Running head : ATTENTIONAL CONTROL IN TLE Attentional control in patients with temporal lobe epilepsy
Across different studies patients with temporal lobe epilepsy (TLE) demonstrate impairments on numerous measures of attentional control that are classically associated with frontal lobe functioning.
Suppression of Prepotent Motor Responses Implicate Frontostriatal Dysfunction in Schizophrenia and Its Subtypes
The Sustained Attention to Response Task, which required occasional withholding of an ongoing frequent response when a specified digit occurred, was completed by patients with a clinical diagnosis of schizophrenia and matched controls and relative to controls, participants with schizophrenia responded less frequently and made more impulsive errors.
Frequency of Attention Deficit in First-Episode Schizophrenia Compared to ADHD
  • J. Egeland
  • Psychology, Medicine
    Applied neuropsychology
  • 2010
Attention deficit in schizophrenia may be underestimated due to limited sensitivity of attention tests. Comparing the frequency of attention deficits in schizophrenia to attention deficit


The state of functioning of working memory in schizophrenia
Deficits in multiple systems of working memory in schizophrenia
Schizophrenics show spatial working memory deficits.
It is demonstrated that schizophrenics are impaired on spatial delayed-response tasks, analogous to those that have been used to assess the working memory function of the dorsolateral prefrontal cortex in rhesus monkeys, and that this deficit is modality independent.
Auditory and visual working memory performance in schizophrenic patients with low scores on the Wisconsin Card Sorting Test
  • G. Grön
  • Medicine, Psychology
    Psychiatry Research
  • 1998
Comparisons of the various group data rule out an unspecified frontal dysfunction of schizophrenic patients with low scores on the Wisconsin Card Sorting Test, as well as normal controls on tasks involving visual and auditory working memory.
Auditory working memory and Wisconsin Card Sorting Test performance in schizophrenia.
Regression analyses suggested that LN span performance predicted the WCST category achieved score, whereas measures of set shifting, verbal fluency, and attention were predictive of perseveration.
Working memory correlates of three symptom clusters in schizophrenia
Evidence is provided that the positive, negative and disorganised symptom dimensions of the PANSS constitute independent clusters, associated with unique patterns of working memory impairment.
Verbal working memory dysfunction in schizophrenia: use of a Brown-Peterson paradigm
Working memory in schizophrenia: transient "online" storage versus executive functioning.
Compared schizophrenia patients to normal comparison subjects in four separate studies are compared and it is recommended that working memory tests be characterized as either transient "online" storage and retrieval tasks or executive-functioning working memory tasks (where storage, manipulation, and retrieval of information is required).
Memory impairment in schizophrenia: a meta-analysis.
A meta-analysis of the published literature on recall and recognition memory performance between patients with schizophrenia and normal comparison subjects revealed a significant and stable association between schizophrenia and memory impairment.