Executive "Brake Failure" following Deactivation of Human Frontal Lobe


In the course of daily living, humans frequently encounter situations in which a motor activity, once initiated, becomes unnecessary or inappropriate. Under such circumstances, the ability to inhibit motor responses can be of vital importance. Although the nature of response inhibition has been studied in psychology for several decades, its neural basis remains unclear. Using transcranial magnetic stimulation, we found that temporary deactivation of the pars opercularis in the right inferior frontal gyrus selectively impairs the ability to stop an initiated action. Critically, deactivation of the same region did not affect the ability to execute responses, nor did it influence physiological arousal. These findings confirm and extend recent reports that the inferior frontal gyrus is vital for mediating response inhibition.

DOI: 10.1162/jocn.2006.18.3.444

Extracted Key Phrases

6 Figures and Tables

Citations per Year

1,996 Citations

Semantic Scholar estimates that this publication has 1,996 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Chambers2006ExecutiveF, title={Executive "Brake Failure" following Deactivation of Human Frontal Lobe}, author={Christopher D. Chambers and Mark A. Bellgrove and Mark G. Stokes and Tracy R. Henderson and Hugh Garavan and Ian H. Robertson and Adam P. Morris and Jason B. Mattingley}, journal={Journal of cognitive neuroscience}, year={2006}, volume={18 3}, pages={444-55} }