Executive/attentional performance and measures of schizotypy in patients with schizophrenia and in their nonpsychotic first-degree relatives

  title={Executive/attentional performance and measures of schizotypy in patients with schizophrenia and in their nonpsychotic first-degree relatives},
  author={Annie Laurent and Michel Biloa-Tang and Thierry Bougerol and Dominique Duly and Anne-Marie Anchisi and Jean-Luc Bosson and Jacques Pellat and Thierry d'Amato and Jean Dal{\'e}ry},
  journal={Schizophrenia Research},
Impaired working speed and executive functions as frontal lobe dysfunctions in young first-degree relatives of schizophrenic patients
The results suggest the need for more time when completing neuropsychological tasks involving selected and focused attention, as well as cognitive flexibility, as a possible indicator of genetic vulnerability to schizophrenia.
Schizotypal Traits are Associated with Poorer Executive Functioning in Healthy Adults
It is found that higher scores on the subscales of unusual experiences, cognitive disorganization, and impulsive non-conformity related to worse performance on a measure of inhibition, and as introvertive anhedonia increased, both attention and processing speed and reasoning and problem-solving performance became more impaired.
Cognitive performance and basic symptoms in first-degree relatives of schizophrenic patients.
  • E. Bove
  • Psychology
    Comprehensive psychiatry
  • 2008
A meta-analytic review of verbal fluency deficits in schizophrenia relative to other neurocognitive deficits
It was concluded that, relative to their general level of intellectual functioning, schizophrenics are not disproportionately impaired on a measure of this construct, the Wisconsin Card Sorting Test (WCST), but verbal fluency tests may be more valid measures of executive functioning as they are more sensitive to the presence of focal frontal lobe injuries.
[The Relationship of Verbal Working Memory and Theory of Mind in First Degree Relatives of Patients With Schizophrenia and Bipolar Disorder].
This is the first study indicating the presence of ToM impairment among first degree relatives of bipolar disorder patients similar to relatives of schizophrenia patients and second order ToM functions in relatives of patients with schizophrenia and bipolar disorder.
Executive function and genetic predisposition to schizophrenia—the Maudsley family study
  • P. Birkett, T. Sigmundsson, R. Murray
  • Psychology, Medicine
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2008
The results suggest that executive deficits qualitatively similar to those seen in those with schizophrenia reflect familial susceptibility, even taking early IQ and education into consideration, consistent with a genetic mechanism.
Tests of executive functions in first-degree relatives of schizophrenic patients: a meta-analysis
Relatives of schizophrenic patients appear to have wide, although not severe, executive dysfunctions, and the sensitivity of the different tests for impairments in relatives is not the same, the choice of test and method should be carefully assessed.


Neuropsychological function in schizophrenia. Selective impairment in memory and learning.
Findings lend support to the hypothesized importance of the temporal-hippocampal region in understanding the pathophysiology of schizophrenia and the selectivity and relative severity compared with other behavioral functions.
Perceptual aberrations, schizotypy, and the Wisconsin Card Sorting Test.
The results provide evidence for subtle WCST performance deficits in subjects hypothesized to be at risk for psychosis--perhaps schizophrenia--and are broadly consistent with current speculation about dorsolateral prefrontal cortex functioning in schizophrenia as well as recent speculation concerning spatial working memory and schizophrenia.
Sustained attention deficit and schizotypal personality features in nonpsychotic relatives of schizophrenic patients.
Sustained attention deficit may be a genetic vulnerability marker for schizophrenia, and it may be more useful in linkage analysis than traditional phenotype definitions of schizophrenia.
Psychometric detection of schizotypy: perceptual aberration and physical anhedonia in relatives of schizophrenics.
Scales of Perceptual Aberration and Physical Anhedonia, traits that may be related to risk for schizophrenia, were administered to 54 schizophrenics and 146 of their first-degree relatives and 178 normal subjects.