Execution of macrophage apoptosis by Mycobacterium avium through apoptosis signal-regulating kinase 1/p38 mitogen-activated protein kinase signaling and caspase 8 activation.

@article{Bhattacharyya2003ExecutionOM,
  title={Execution of macrophage apoptosis by Mycobacterium avium through apoptosis signal-regulating kinase 1/p38 mitogen-activated protein kinase signaling and caspase 8 activation.},
  author={Asima Bhattacharyya and Shresh Pathak and Chaitali Basak and Sujata Law and Manikuntala Kundu and Joyoti Basu},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 29},
  pages={26517-25}
}
Macrophage apoptosis is an important component of the innate immune defense machinery (against pathogenic mycobacteria) responsible for limiting bacillary viability. However, little is known about the mechanism of how apoptosis is executed in mycobacteria-infected macrophages. Apoptosis signal-regulating kinase 1 (ASK1) was activated in Mycobacterium avium-treated macrophages and in turn activated p38 mitogen-activated protein (MAP) kinase. M. avium-induced macrophage cell death could be… CONTINUE READING
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