Excretion profiles and half-lives of ten urinary polycyclic aromatic hydrocarbon metabolites after dietary exposure.

@article{Li2012ExcretionPA,
  title={Excretion profiles and half-lives of ten urinary polycyclic aromatic hydrocarbon metabolites after dietary exposure.},
  author={Zheng Li and Lovisa C Romanoff and Scott M. Bartell and Erin N Pittman and Debra A Trinidad and Michael D Mcclean and Thomas F. Webster and Andreas Sj{\"o}din},
  journal={Chemical research in toxicology},
  year={2012},
  volume={25 7},
  pages={1452-61}
}
Human exposure to polycyclic aromatic hydrocarbons (PAHs) can be assessed by biomonitoring of their urinary monohydroxylated metabolites (OH-PAHs). Limited information exists on the human pharmacokinetics of OH-PAHs. This study aimed to investigate the excretion half-life of 1-hydroxypyrene (1-PYR), the most used biomarker for PAH exposure, and 9 other OH-PAHs following a dietary exposure in 9 nonsmoking volunteers with no occupational exposure to PAHs. Each person avoided food with known high… CONTINUE READING