Excretion pattern investigation of urinary normal and modified nucleosides of breast cancer patients by RP-HPLC and factor analysis method.

@article{Xu2000ExcretionPI,
  title={Excretion pattern investigation of urinary normal and modified nucleosides of breast cancer patients by RP-HPLC and factor analysis method.},
  author={Guo-Wang Xu and Heike Schmid and Xiu-qing Lu and Hartmut M. Liebich and Peizhang Lu},
  journal={Biomedical chromatography : BMC},
  year={2000},
  volume={14 7},
  pages={
          459-63
        }
}
Modified nucleosides, formed post-transcriptionally in RNA by a number of modification enzymes, are excreted in abnormal levels in the urine of patients with malignant tumors. To test their usefulness as tumor markers, and to compare them with the conventional tumor markers, a reversed-phase high-performance liquid chromatographic (RP-HPLC) method and a factor analysis method have been used to study the excretion pattern of nucleosides of breast cancer patients. A clear cut differentiation of… CONTINUE READING

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