Excretion of methylhippuric acids in urine of workers exposed to a xylene mixture: comparison among three xylene isomers and toluene

@article{Inoue1993ExcretionOM,
  title={Excretion of methylhippuric acids in urine of workers exposed to a xylene mixture: comparison among three xylene isomers and toluene},
  author={Osamu Inoue and Kazunori Seiji and Toshio Kawai and T. Watanabe and C Jin and S X Cai and Zhao-hong Chen and Q S Qu and T Zhang and Masayuki Ikeda},
  journal={International Archives of Occupational and Environmental Health},
  year={1993},
  volume={64},
  pages={533-539}
}
  • O. Inoue, K. Seiji, +7 authors M. Ikeda
  • Published 1993
  • Chemistry, Medicine
  • International Archives of Occupational and Environmental Health
SummaryThe correlation between exposure to three xylene isomers and resulting urinary excretion of corresponding methylhippuric acid (MHA) isomers was studied among 175 Chinese workers of both sexes who had been predominantly exposed to xylenes (exposure to xylenes accounting for 70% or more of the total exposure on a ppm basis). Nonexposed controls (281 men and women) were also studied to define the background level of MHAs in urine. The solvent exposure of xylene-exposed workers during their… Expand
Exposure of workers to a mixture of toluene and xylenes. I. Metabolism.
TLDR
The metabolism of toluene and xylenes was significantly reduced among smokers or drinkers compared with non-smokers and non-drinkers and no difference was found in the correlation between quantitative exposure and excretion in the three xylene isomers. Expand
Relationship Between Exposure to Xylenes and Ethylbenzene Expressed Either in Concentration in Air and Amount of Their Metabolites Excreted in the Urine
The urinary excretion of methylhippurics, mandelic and phenylglyoxylic acids was studied in histopathological technicians (102 subjects; 14 men and 88 women) exposed to Xylol (xylenes andExpand
Urinary Phenylglyoxylic Acid Excretion after Exposure to Ethylbenzene among Solvent-exposed Chinese Workers.
  • Inoue, Seiji, +6 authors Ikeda
  • Chemistry, Medicine
  • International journal of occupational and environmental health
  • 1995
TLDR
A significant correlation was observed between ethylbenzene exposure and urinary phenylglyoxylic acid, with high (0.6-0.7) correlation coefficients, suggesting that urinary Phenylgly Oxylic acid is a good marker of occupational exposure to ethyl Benzene. Expand
Possible preferential metabolism of xylene isomers following occupational exposure to mixed xylenes
  • M. Miller, J. Edwards
  • Chemistry, Medicine
  • International archives of occupational and environmental health
  • 1999
TLDR
This study suggests that excretion of m-MHA in urine is favoured over that of the other isomers following exposure to mixed xylenes, independent of airborne xylene isomer composition. Expand
Environmental exposure to xylenes in drivers and petrol station workers by urinary methylhippuric Acid.
TLDR
Urinary MHA level has a poor correlation with exposure to xylenes in drivers but has good correlation in petrol station workers, and high xylene levels are emitted in petrol stations at Iran. Expand
Biological monitoring of low level occupational xylene exposure and the role of recent exposure.
TLDR
Biological monitoring of occupational xylene exposure at levels <15 p.p.m.m using urinary MHA showed a good correlation with atmospheric levels and is a valid complement to ambient monitoring, even though occupationalxylene exposure in the workplaces studied was generally low. Expand
New approaches to the metabolism of xylenes: verification of the formation of phenylmercapturic acid metabolites of xylenes
TLDR
The results show that irrespective of the structure of xylene isomers there is no preferences in metabolism, and MHA should be used for biomonitoring from now on. Expand
Effects of methanol on styrene metabolism among workers occupationally exposed at low concentrations
TLDR
Compared with a previous survey, the comparison showed no evidence to suggest that styrene metabolism is suppressed by coexposure to methanol and methyl acetate at low concentrations below the current occupational exposure limit of 200 ppm. Expand
Toxicity of xylene in occupationally exposed workers: A high-performance liquid chromatography analysis
TLDR
Various side effects of xylene including respiratory, dermatological, neurological and gastrointestinal symptoms were observed among the study groups and the P value was found to be highly significant. Expand
Effects of smoking and drinking habits on urinary o-cresol excretion after occupational exposure to toluene vapor among Chinese workers.
TLDR
Urinary o-cresol level was significantly reduced by smoking, drinking, and the two habits combined, it cannot be considered reliable as an indicator of exposure to toluene and is not a suitable biological marker for detecting low level toLUene exposure. Expand
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References

SHOWING 1-10 OF 24 REFERENCES
Urinary methylhippuric acid isomer levels after occupational exposure to a xylene mixture
TLDR
There is a linear relationship between the intensity of exposure to xylenes and the concentration of MHA in urine, that the regression line passes very close to the origin, and that the increment in observed MHA concentrations as a function of increasing xylene concentration was 17.8 mg × 1−1 ppm−1. Expand
Toluene vapor exposure and urinary excretion of hippuric acid among workers in China.
TLDR
Comparison of the results with findings in the literature shows that the toluene-induced increase in urinary HA concentration among workers in China is significantly smaller than the published values, whereas HA concentrations in urine samples from nonexposed controls are comparable to the levels previously reported. Expand
Evaluation of occupational exposure to xylene by blood, exhaled air and urine analysis.
TLDR
Xylene concentrations in exhaled air and blood sampled after the workday correlated poorly to the exposure of the preceding day, and the urinary elimination of methylhippuric acid after the finished work week showed two distinct phases of excretion. Expand
Relationship between vapor exposure and urinary metabolite excretion among workers exposed to trichloroethylene.
TLDR
Investigation of the exposure-excretion relationship in trichloroethylene-exposed workers revealed that about 4% of TRI absorbed will be excreted at the end of the shift, in agreement with the long biological half-life of this chlorinated hydrocarbon solvent. Expand
Exposure test for xylenes
  • V. Šedivec, J. Flek
  • Chemistry, Medicine
  • International archives of occupational and environmental health
  • 1976
TLDR
It has been proved by studies of the course of toluic acid excretion that short-term samples of urine from the last 2 h of the shift are not suitable for estimation of the level of exposure, if the exposure is interrupted or if the vapor concentration in the atmosphere changes. Expand
Kinetics of m-xylene in man: General features of absorption, distribution, biotransformation and excretion in repetitive inhalation exposure.
TLDR
Observations are congruent with the concept that xylene is distributed to at least two main tissue compartments in the body, and the slow elimination takes place from tissues with a high xylene solubility and a small perfusion, for example, adipose tissue; in this compartment cumulation of xylene occurs over repeated exposures. Expand
Effects of smoking and drinking on excretion of hippuric acid among toluene-exposed workers
  • O. Inoue, K. Seiji, +4 authors M. Ikeda
  • Chemistry, Medicine
  • International archives of occupational and environmental health
  • 1993
TLDR
Regression analysis after classification of the subjects by smoking and drinking clearly demonstrated that the two social habits, when combined, markedly reduce the hippuric acid level in the urine of workers exposed to toluene, suggesting that the observed effects may be attributable to smoking rather than to drinking habits. Expand
Dose-excretion relationship in tetrachloroethylene-exposed workers and the effect of tetrachloroethylene co-exposure on trichloroethylene metabolism.
TLDR
Urinary metabolite levels were markedly lower in the mixed (TETRA + TRI) exposure group as compared to previous findings in a group exposed to TRI alone, indicating that metabolism of TRI is suppressed by the co-exposure to TETRA in humans. Expand
URINARY EXCRETION OF PHENOL BY MEN EXPOSED TO VAPOUR OF BENZENE: A SCREENING TEST
TLDR
A semi-quantitative screening test using stable reagents not requiring special apparatus or laboratory facilities permits an estimation of urinary phenolic bodies, and hence the exposure to benzene. Expand
Symptoms and signs in workers exposed predominantly to xylenes
TLDR
It was observed that the findings of hematology and serum biochemistry in respect of liver and kidney functions were generally negative, showing that xylenes are not toxic to the hematopoietic organs, the liver, or the kidney. Expand
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