Excretion of foetal bilirubin by the rat placenta-maternal liver tandem.

@article{Briz2003ExcretionOF,
  title={Excretion of foetal bilirubin by the rat placenta-maternal liver tandem.},
  author={{\'O}scar Briz and Rocio I R Macias and M Antonia Serrano and Javier Gonz{\'a}lez-Gallego and Jose E B{\'a}yon and Jose J G Marin},
  journal={Placenta},
  year={2003},
  volume={24 5},
  pages={462-72}
}
Using plasma membrane vesicles from human trophoblast, carrier-mediated transport of unconjugated bilirubin (UCBR) has been reported. In the present work, using the in situ perfused rat placenta-maternal liver tandem, the relevance of this pathway in vivo was investigated. After single-pass perfusion of rat placenta through the umbilical artery with 0.25 micromol [(3)H]-UCBR, approximately 15 per cent of it was taken up by the placenta, detected in maternal serum (>96 per cent was unconjugated… CONTINUE READING

Similar Papers

Loading similar papers…