Excretion of chlordecone by the gastrointestinal tract: evidence for a nonbiliary mechanism.

@article{Boylan1979ExcretionOC,
  title={Excretion of chlordecone by the gastrointestinal tract: evidence for a nonbiliary mechanism.},
  author={James J. Boylan and Walter Cohn and Jochem Egle and Robert Vernon. Blanke and Philip S. Guzelian},
  journal={Clinical pharmacology and therapeutics},
  year={1979},
  volume={25 5 Pt 1},
  pages={
          579-85
        }
}
Workers exposed to chlordecone (Kepone), a toxic organochlorine pesticide, excreted larger amounts of chlordecone in bile than in stool, suggesting that it may undergo enterohepatic recirculation. We found in a single subject that equal amounts of chlordecone and of its reduced metabolite, chlordecone alcohol, were excreted in bile at a rate four times as great as in stool. When biliary contents were diverted from the intestine through a T tube, fecal excretion of chlordecone alcohol was… CONTINUE READING
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