Excretion of Quazepam Into Human Breast Milk

@article{Hilbert1984ExcretionOQ,
  title={Excretion of Quazepam Into Human Breast Milk},
  author={James M. Hilbert and Richard Gural and Samson Symchowicz and Nicola Zampaglione},
  journal={The Journal of Clinical Pharmacology},
  year={1984},
  volume={24}
}
Abstract: Previous metabolic studies have established that two major metabolites, 2‐oxoquazepam and N‐desalkyl‐2‐oxoquazepam, are present in plasma after dosing with quazepam, a new benzodiazepine hypnotic. The excretion of quazepam, 2‐oxoquazepam, and N‐desalkyl‐2‐oxoquazepam into human breast milk was studied in four lactating nonpregnant volunteers. Each volunteer received one 15‐mg quazepam tablet following an overnight fast. Nursing of offspring was discontinued after drug administration… 
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Quazepam. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in insomnia.
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Preliminary evidence suggests that quazepam 15 to 30 mg is as effective as flurAZepam and triazolam in usual therapeutic doses, and causes minimal rebound insomnia following its withdrawal, unlike rapidly eliminated benzodiazepines such as triazlam.
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List of the pharmacologic or chemical agents transferred into human milk and their possible effects on the infant or on lactation, if known, are provided.
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The lists of agents transferred into human milk are revised and described to describe their possible effects on the infant or on lactation, if known (Tables I through 7).
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References

SHOWING 1-10 OF 15 REFERENCES
Multiple‐dose quazepam kinetics
TLDR
These kinetic profiles may explain the clinical hypnotic effect of quazepam—rapid induction of sleep and long duration of clinical action without appreciable rebound insomnia.
Disposition and metabolic fate of 14C-quazepam in man.
The absorption, metabolism, and excretion of quazepam, a new benzodiazepine hypnotic, was investigated in six normal male volunteers after oral administration of 25 mg 14C-quazepam in solution.
Effect of sleep on quazepam kinetics
TLDR
In general, time of dosing had no appreciable effect on quazepam kinetics or those of its major active plasma metabolites, and the small differences between the two dose times are expected to have clinical significance.
Excretion of drugs in human breast milk.
TLDR
It is projected, from estimated steady-state milk concentrations of the drugs and their metabolites studied, that very low percentages of the therapeutic dosages would be excreted in mother's milk, too low an amount to be clinically significant to the infant.
Pharmacological studies with quazepam, a new benzodiazepine hypnotic.
TLDR
Results suggest that quazepam is likely to be a safe and effective sleep-promoting agent and potent anticonvulsant activity.
Gas chromatographic determination of quazepam and two major metabolites in human plasma.
Two rapid, sensitive, and specific gas chromatographic (GC) methods for the quantitative determination of quazepam (I), 7-chloro-5-(2-fluorophenyl-1,3-dihydro-1-(2,2,2-trifluoroethyl)
Drug Excretion in Human Breast Milk
TLDR
Fundamental principles of breast milk excretion are used to construct a pharmacokinetic approach useful for the study of most drugs, but data are lacking for most drugs and hence dosing via milk or risk to the infant remains speculative.
Dose‐response studies of quazepam
TLDR
The efficacy and comparatively less severe side effects of the 7.5‐and 15‐mg doses of quazepam suggest that these doses may be optimal when the drug is considered for the adjunctive treatment of insomnia.
Quazepam and flurazepam: Long‐term use and extended withdrawal
TLDR
The data suggest that the optimal dose of quazepam is 15 mg, and some loss of effectiveness was noted during long‐term use of both doses of quzepam and, to a lesser extent, of flurazepams.
The sedative-hypnotic properties of quazepam, a new hypnotic agent.
TLDR
In conscious, unrestrained squirrel monkeys and cats, quazepam produced sedation with less ataxia and less evidence of CNS stimulant action than flurazepAM, which should be an effective hypnotic with less potential for ataxIA, paradoxical excitation, and tolerance than florinol.
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