Excretion of GSSG and glutathione conjugates mediated by MRP1 and cMOAT/MRP2.

@article{Suzuki1998ExcretionOG,
  title={Excretion of GSSG and glutathione conjugates mediated by MRP1 and cMOAT/MRP2.},
  author={Hodaka Suzuki and Yuichi Sugiyama},
  journal={Seminars in liver disease},
  year={1998},
  volume={18 4},
  pages={359-76}
}
It has been shown that both multidrug resistance-associated protein (MRP1) and canalicular multispecific organic anion transporter (cMOAT/MRP2) have the ability to extrude glutathione conjugates (GS-X pump activity)from cells. Therefore, they play an important role in the detoxification of xenobiotics. Using mrp1-knockout mice, it has recently been shown that MRP1/mrp1 has an important role in the export of leukotriene C4 (LTC4), a mediator of inflammation, and in protecting the body from a… CONTINUE READING
54 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 54 extracted citations

Similar Papers

Loading similar papers…