Excretion of Dicarboxylic and ω-1 Hydroxy Fatty Acids by Low Birth Weight Infants Fed with Medium-Chain Triglycerides

  title={Excretion of Dicarboxylic and $\omega$-1 Hydroxy Fatty Acids by Low Birth Weight Infants Fed with Medium-Chain Triglycerides},
  author={Robin K. Whyte and Donald T. Whelan and Robert Elkin Hill and Shannon McClorry},
  journal={Pediatric Research},
ABSTRACT. The effects of feeding a commercial formula containing increased amounts of medium-chain fatty acids on the urinary excretions of C6-C10 moncarboxylic, dicarboxylic, and ω- 1 hydroxy acids were studied in 13 growing preterm infants of mean birth weight 1.42 kg in a randomized double-blind cross-over clinical trial. Infants were allocated to two sequential feeding regimes of 5 days each, during the last 3 days of which urine was collected and analysed by gas-chromatography mass… Expand
Conversion of octanoic acid into long-chain saturated fatty acids in premature infants fed a formula containing medium-chain triglycerides.
To study the nonoxidative metabolism of MCT, six preterm infants fed a standard premature formula containing 38 weight% MCT were studied at 4 weeks of age, and the plasma TG fatty acid profile differed markedly from the diet. Expand
Role of carnitine in utilization of dietary medium-chain triglycerides by term infants.
Results are consistent with a role for carnitine in metabolism of dietary medium-chain triglycerides in infants and urinary acylcarnitine excretion was significantly higher and the ratio of free to total carnitines was significantly lower when infants were fed the formula with medium- chain triglycerides. Expand
Dietary Medium-Chain Triglycerides: A Source of Urinary Dicarboxylic Acids and Diagnostic Confusion
D elivery of proper nutrition is a primary concern among the many clinical problems faced by the medical caretaker of a significantly ill, hospitalized infant or child. With the availability ofExpand
Quantisation of Oxidation of Medium-Chain Triglycerides in Preterm Infants1
ABSTRACT: Medium-chain triglycerides, with a chain length of eight and 10 carbon atoms, form up to 50% of the total fat content in some preterm infant formulas. In 20 small preterm infants (birthwt:Expand
Effects of medium-chain triglyceride feeding on energy balance in adult humans.
The data suggest MCT sustain energy expenditure through medium-chain fatty acid (MCFA) oxidation with no decrease in citric acid cycle intermediates, while sparing protein oxidation. Expand
Energy balance in low birth weight infants fed formula of high or low medium-chain triglyceride content.
The use of high MCT content in infant formula neither provided a nutritional advantage in energy digestibility or metabolizability nor resulted in an increased rate of energy expenditure or of energy storage. Expand
Carnitine Supplementation and Ketogenesis by Small-For-Date Neonates on Medium- and Long-Chain Fatty Acid Formulae
There was a statistically significant interaction between carnitine and the chain length of the administered fat with respect to ketone production and this results provide further evidence for the involvement of carnitines in medium-chain triglyceride metabolism. Expand
Exploring the metabolic fate of medium-chain triglycerides in healthy individuals using a stable isotope tracer.
The data show that in resting healthy individuals only a very small part of the MCT is traced back as LCFA in plasma, suggesting that MCT treatment does not result in a large LCFA burden, however further research on storage of MCT in tissues is warranted. Expand
The metabolic response to intravenous medium-chain triglycerides in infants after surgery.
Providing that carbohydrate calories do not exceed REE, partial replacement of LCT by MCT in intravenous fat emulsions can increase net fat oxidation in infants after surgery. Expand
Novel glycine conjugates in medium-chain acyl-CoA dehydrogenase deficiency
  • J. Pitt
  • Chemistry, Medicine
  • Journal of Inherited Metabolic Disease
  • 2004
It is suggested that the glycine conjugates of isocaproic acid and 4-methylhexanoic acid are metabolites of branched-chain fatty acids and that they are specific for MCAD deficiency. Expand


Energy Balance and Nitrogen Balance in Growing Low Birthweight Infants Fed Human Milk or Formula
Summary: Energy and nitrogen balances were measured in growing low birthweight infants fed either mother's expressed breast milk or a 20 kcal per ounce formula to determine whether or not there wereExpand
Effect of the fatty acid composition of ingested fats on rat liver intermediatry metabolism
  • Horm Metab Res
  • 1976