Exclusive expression of MHC class II proteins on CD45+ cells in pancreatic islets of NOD mice.

@article{McInerney1991ExclusiveEO,
  title={Exclusive expression of MHC class II proteins on CD45+ cells in pancreatic islets of NOD mice.},
  author={Marcia F. McInerney and Satyajit Rath and Charles A. Janeway},
  journal={Diabetes},
  year={1991},
  volume={40 5},
  pages={648-51}
}
The expression of MHC class II molecules on beta-cells of the pancreatic islet has been proposed to play a role in the genesis of insulin-dependent diabetes mellitus in the NOD mouse. We investigated this by immunofluorescent double labeling of islet cells with anti-MHC and anti-CD45 to identify cells of hematopoietic origin. MHC class I expression increased with age on CD45- islet cells. MHC class II expression was not observed on CD45- islet cells at any age; the only cells in the islet that… CONTINUE READING