Exclusive Association of p53 Mutation with Super-High Methylation of Tumor Suppressor Genes in the p53 Pathway in a Unique Gastric Cancer Phenotype

@inproceedings{Waraya2015ExclusiveAO,
  title={Exclusive Association of p53 Mutation with Super-High Methylation of Tumor Suppressor Genes in the p53 Pathway in a Unique Gastric Cancer Phenotype},
  author={Mina Waraya and Keishi Yamashita and Akira Ema and Natsuya Katada and Shiro Kikuchi and Masahiko Watanabe and Qian Tao},
  booktitle={PloS one},
  year={2015}
}
BACKGROUND A comprehensive search for DNA methylated genes identified candidate tumor suppressor genes that have been proven to be involved in the apoptotic process of the p53 pathway. In this study, we investigated p53 mutation in relation to such epigenetic alteration in primary gastric cancer. METHODS The methylation profiles of the 3 genes: PGP9.5, NMDAR2B, and CCNA1, which are involved in the p53 tumor suppressor pathway in combination with p53 mutation were examined in 163 primary… CONTINUE READING
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