Exclusion of eleven candidate genes for ocular melanosis in cairn terriers

  title={Exclusion of eleven candidate genes for ocular melanosis in cairn terriers},
  author={Paige A. Winkler and Joshua T. Bartoe and Celeste R Quinones and Patrick J. Venta and Simon Michael Petersen-Jones},
  booktitle={Journal of Negative Results in BioMedicine},
Ocular melanosis of Cairn terrier dogs is an inherited defect characterized by progressive pigmentation of both eyes which can result in glaucoma and blindness. Pedigree analysis suggests the trait has an autosomal dominant mode of inheritance. We selected 11 potential candidate genes and used an exclusion analysis approach to investigate the likelihood that one of the candidate gene loci contained the Cairn terrier-ocular melanosis locus. Two polymorphic loci were identified within or close to… CONTINUE READING
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