Exclusion of a p53 germline mutation in a classic Li-Fraumeni syndrome family

Abstract

Li-Fraumeni syndrome (LFS) is characterized by a high risk of sarcomas, early onset of breast cancer, and a diversity of other cancers occurring as multiple primary tumors in multiple family members. In many families with LFS, germline mutations within the tumor-suppressor gene p53 have been identified. However, mutations in p53 have not been detected in… (More)
DOI: 10.1007/s004390050761

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