Exclusion of Cx43 gene mutation as a major cause of criss-cross heart anomaly in man.

@article{Luca2010ExclusionOC,
  title={Exclusion of Cx43 gene mutation as a major cause of criss-cross heart anomaly in man.},
  author={Alessandro De Luca and Anna Sarkozy and Federica Consoli and Andrea de Zorzi and Rita Mingarelli and Maria Christina Digilio and Bruno Marino and Bruno Dallapiccola},
  journal={International journal of cardiology},
  year={2010},
  volume={144 2},
  pages={300-2}
}
Criss-cross heart is a rare congenital cardiac defect characterized by crossing of the atrioventricular valves and of the inflow streams due to the twisting of the ventricles about their long axis. The aetiology of criss-cross heart has not been understood yet. Mice homozygous for Cx43 deficiency show a delay in normal looping of ascending limb of the heart tube, which temporarily retains a more symmetric middle position. Persistence of this condition results in a "criss-cross" configuration… CONTINUE READING

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