Exclusion of BRAFV599E as a melanoma susceptibility mutation.

Abstract

Very recently, BRAF mutations were found in about 2/3 of malignant melanomas and at lower frequencies in other human cancers. The BRAF gene codes for a protein in the mitogen-activated protein kinase (MAPK) pathway. All mutations identified to date are within the kinase domain, with a single missense mutation (V599E) accounting for 80%. We investigated the… (More)

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@article{Meyer2003ExclusionOB, title={Exclusion of BRAFV599E as a melanoma susceptibility mutation.}, author={Peter Meyer and Ruediger Klaes and Christina S Schmitt and Melanie B{\"o}ttger and Claus Garbe}, journal={International journal of cancer}, year={2003}, volume={106 1}, pages={78-80} }