Exclusion from the Golgi and very low levels of HTLV-2 Tax ubiquitination do not prevent IKK-gamma/NEMO relocalization and NF-κB activation

Abstract

Permanent activation of the NFB pathway by the HTLV-1 Tax (Tax1) viral transactivator is a key event in the induction of T-cell immortalization and participates in HTLV-1-induced leukemogenesis. Tax1-induced NFB activation occurs through the ubiquitin-dependent recruitment of the IKK-gamma/NEMO regulatory subunit in centrosome/Golgi-associated cytoplasmic… (More)
DOI: 10.1186/1742-4690-8-S1-A134

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