Excitotoxicity, synaptic repair, and functional recovery in the mammalian cochlea: a review of recent findings.

@article{Pujol1999ExcitotoxicitySR,
  title={Excitotoxicity, synaptic repair, and functional recovery in the mammalian cochlea: a review of recent findings.},
  author={R{\'e}my Pujol and Jean Luc Puel},
  journal={Annals of the New York Academy of Sciences},
  year={1999},
  volume={884},
  pages={249-54}
}
Besides its fast excitatory properties, glutamate is known to have neurotoxic properties when released in large amounts or when incompletely recycled. This so-called excitotoxicity is involved in a number of acute and/or degenerative forms of neuropathology such as epilepsy, Alzheimer's, Parkinson's, stroke, and retinal ischemia. In the cochlea, excitotoxicity may occur in two pathological conditions: anoxia and noise trauma. It is characterized by a two-step mechanism: (1) An acute swelling… CONTINUE READING

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