Excitotoxicity, Synaptic Repair, and Functional Recovery in the Mammalian Cochlea: A Review of Recent Findings

@article{Pujol1999ExcitotoxicitySR,
  title={Excitotoxicity, Synaptic Repair, and Functional Recovery in the Mammalian Cochlea: A Review of Recent Findings},
  author={Re´my Pujol and Jean-Luc Puel},
  journal={Annals of the New York Academy of Sciences},
  year={1999},
  volume={884}
}
  • R. Pujol, J. Puel
  • Published 1 November 1999
  • Biology
  • Annals of the New York Academy of Sciences
ABSTRACT: Besides its fast excitatory properties, glutamate is known to have neurotoxic properties when released in large amounts or when incompletely recycled. This so‐called excitotoxicity is involved in a number of acute and/or degenerative forms of neuropathology such as epilepsy, Alzheimer's, Parkinson's, stroke, and retinal ischemia. In the cochlea, excitotoxicity may occur in two pathological conditions: anoxia and noise trauma. It is characterized by a two‐step mechanism: (1) An acute… 
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Perinatal hipoxic ischemic injury in the auditory pathway and the effect of several neuroprotective agents
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