Excitotoxic motoneuron degeneration induced by glutamate receptor agonists and mitochondrial toxins in organotypic cultures of chick embryo spinal cord.

@article{Brunet2009ExcitotoxicMD,
  title={Excitotoxic motoneuron degeneration induced by glutamate receptor agonists and mitochondrial toxins in organotypic cultures of chick embryo spinal cord.},
  author={N{\'u}ria Molist Brunet and Olga Tarabal and Josep E. Esquerda and Jordi Calder{\'o}},
  journal={The Journal of comparative neurology},
  year={2009},
  volume={516 4},
  pages={277-90}
}
Glutamate receptor-mediated excitotoxicity and mitochondrial dysfunction appear to play an important role in motoneuron (MN) degeneration in amyotrophic lateral sclerosis (ALS). In the present study we used an organotypic slice culture of chick embryo spinal cord to explore the responsiveness of mature MNs to different excitotoxic stimuli and mitrochondrial inhibition. We found that, in this system, MNs are highly vulnerable to excitotoxins such as glutamate, N-methyl-D-aspartate (NMDA), and… CONTINUE READING
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