Excitotoxic loss of post-synaptic sites is distinct temporally and mechanistically from neuronal death.

@article{Waataja2008ExcitotoxicLO,
  title={Excitotoxic loss of post-synaptic sites is distinct temporally and mechanistically from neuronal death.},
  author={Jonathan J Waataja and Hee Jung Kim and Alan M Roloff and Stanley A Thayer},
  journal={Journal of neurochemistry},
  year={2008},
  volume={104 2},
  pages={364-75}
}
Dendritic degeneration and loss of synaptic proteins are early events correlated with functional decline in neurodegenerative disease. The temporal and mechanistic relationship between synapse loss and cell death, however, remains unclear. We used confocal microscopy and image processing to count post-synaptic sites on rat hippocampal neurons by expressing post-synaptic density protein 95 fused to green fluorescent protein. Fluorescent puncta co-localized with neurotransmitter release sites… CONTINUE READING

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