Excitotoxic degeneration is initiated at non-random sites in cultured rat cerebellar neurons

@inproceedings{Bindokas1995ExcitotoxicDI,
  title={Excitotoxic degeneration is initiated at non-random sites in cultured rat cerebellar neurons},
  author={V. Bindokas and R. Miller},
  booktitle={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1995}
}
Prolonged stimulation of cultured cerebellar neurons by kainic acid (KA) leads to death of neurons first evident from the swelling of soma and neurites. Stimulation is accompanied by increases in [Ca2+]i and [Na+]i as monitored using digital imaging microfluorimetry. “Blebs” tended to form on neurites with the highest increases in [Ca2+]i. Points of Ca2+ entry into neurites via glutamate-receptor-gated channels predicted where approximately 80% of blebs would form tens of minutes later. These… Expand
Changes in Mitochondrial Function Resulting from Synaptic Activity in the Rat Hippocampal Slice
Don't get too excited: mechanisms of glutamate-mediated Purkinje cell death.
Mitochondria and neuronal glutamate excitotoxicity.
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