Excitotoxic and excitoprotective mechanisms

@article{Mattson2007ExcitotoxicAE,
  title={Excitotoxic and excitoprotective mechanisms},
  author={M. Mattson},
  journal={NeuroMolecular Medicine},
  year={2007},
  volume={3},
  pages={65-94}
}
  • M. Mattson
  • Published 2007
  • Biology, Medicine
  • NeuroMolecular Medicine
  • Activation of glutamate receptors can trigger the death of neurons and some types of glial cells, particularly when the cells are coincidentally subjected to adverse conditions such as reduced levels of oxygen or glucose, increased levels of oxidative stress, exposure to toxins or other pathogenic agents, or a disease-causing genetic mutation. Such excitotoxic cell death involves excessive calcium influx and release from internal organelles, oxyradical production, and engagement of programmed… CONTINUE READING
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