• DOI:10.1385/NMM:3:2:65
Corpus ID: 13181891

Excitotoxic and excitoprotective mechanisms

@article{Mattson2007ExcitotoxicAE,
  title={Excitotoxic and excitoprotective mechanisms},
  author={M. Mattson},
  journal={NeuroMolecular Medicine},
  year={2007},
  volume={3},
  pages={65-94}
}

M. Mattson

Published 2007

Biology, Medicine

NeuroMolecular Medicine

Activation of glutamate receptors can trigger the death of neurons and some types of glial cells, particularly when the cells are coincidentally subjected to adverse conditions such as reduced levels of oxygen or glucose, increased levels of oxidative stress, exposure to toxins or other pathogenic agents, or a disease-causing genetic mutation. Such excitotoxic cell death involves excessive calcium influx and release from internal organelles, oxyradical production, and engagement of programmed… CONTINUE READING

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