Excitotoxic Lesions of the Rat Medial Prefrontal Cortex: Effects on Abnormal Behaviors Associated with Neonatal Hippocampal Damage

@article{Lipska1998ExcitotoxicLO,
  title={Excitotoxic Lesions of the Rat Medial Prefrontal Cortex: Effects on Abnormal Behaviors Associated with Neonatal Hippocampal Damage},
  author={Barbara K. Lipska and Hassen A Al-Amin and Daniel R. Weinberger},
  journal={Neuropsychopharmacology},
  year={1998},
  volume={19},
  pages={451-464}
}
Neonatal excitotoxic damage of the ventral hippocampus (VH) is a heuristic model of schizophrenia. We investigated whether: (1) neonatal damage of the medial prefrontal cortex (mPFC) has effects similar to the neonatal VH lesion; and (2) intrinsic mPFC neurons contribute to the abnormal behaviors associated with VH lesions. Neonatal rats were lesioned in the mPFC. In adulthood, they showed attenuated locomotion in response to novelty, amphetamine, and MK-801, and enhanced apomorphine-induced… CONTINUE READING

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