Excitatory synaptic input to granule cells increases with time after kainate treatment.

  title={Excitatory synaptic input to granule cells increases with time after kainate treatment.},
  author={J P Wuarin and F. Edward Dudek},
  journal={Journal of neurophysiology},
  volume={85 3},
Temporal lobe epilepsy is usually associated with a latent period and an increased seizure frequency following a precipitating insult. After kainate treatment, the mossy fibers of the dentate gyrus are hypothesized to form recurrent excitatory circuits between granule cells, thus leading to a progressive increase in the excitatory input to granule cells. Three groups of animals were studied as a function of time after kainate treatment: 1-2 wk, 2-4 wk, and 10-51 wk. All the animals studied 10… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 68 extracted citations

Recurrent mossy fibers establish aberrant kainate receptor-operated synapses on granule cells from epileptic rats.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2005
View 4 Excerpts
Highly Influenced

Rapamycin suppresses the recurrent excitatory circuits of dentate gyrus in a mouse model of temporal lobe epilepsy.

Biochemical and biophysical research communications • 2012
View 8 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 40 references

Similar Papers

Loading similar papers…