Excitatory synaptic input to granule cells increases with time after kainate treatment.

@article{Wuarin2001ExcitatorySI,
  title={Excitatory synaptic input to granule cells increases with time after kainate treatment.},
  author={J P Wuarin and F. Edward Dudek},
  journal={Journal of neurophysiology},
  year={2001},
  volume={85 3},
  pages={1067-77}
}
Temporal lobe epilepsy is usually associated with a latent period and an increased seizure frequency following a precipitating insult. After kainate treatment, the mossy fibers of the dentate gyrus are hypothesized to form recurrent excitatory circuits between granule cells, thus leading to a progressive increase in the excitatory input to granule cells. Three groups of animals were studied as a function of time after kainate treatment: 1-2 wk, 2-4 wk, and 10-51 wk. All the animals studied 10… CONTINUE READING
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