Excitatory synapses in the rat superficial dorsal horn are strengthened following peripheral inflammation during early postnatal development.

@article{Li2009ExcitatorySI,
  title={Excitatory synapses in the rat superficial dorsal horn are strengthened following peripheral inflammation during early postnatal development.},
  author={Jie Li and Mark L Baccei},
  journal={Pain},
  year={2009},
  volume={143 1-2},
  pages={56-64}
}
Peripheral inflammation can cause prolonged changes in pain sensitivity if it occurs during a critical period of early postnatal development, suggesting that neonatal pain circuits respond to tissue damage in a fundamentally different manner. However, the effects of early tissue injury on the function of emergent central pain networks have yet to be characterized at the synaptic level. Here, we investigated whether inflammation at different postnatal ages has distinct consequences for synaptic… CONTINUE READING
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