Excitatory synapses in the rat superficial dorsal horn are strengthened following peripheral inflammation during early postnatal development

@article{Li2009ExcitatorySI,
  title={Excitatory synapses in the rat superficial dorsal horn are strengthened following peripheral inflammation during early postnatal development},
  author={J. Li and M. Baccei},
  journal={Pain},
  year={2009},
  volume={143},
  pages={56-64}
}
ABSTRACT Peripheral inflammation can cause prolonged changes in pain sensitivity if it occurs during a critical period of early postnatal development, suggesting that neonatal pain circuits respond to tissue damage in a fundamentally different manner. However, the effects of early tissue injury on the function of emergent central pain networks have yet to be characterized at the synaptic level. Here, we investigated whether inflammation at different postnatal ages has distinct consequences for… Expand
Modulation of developing dorsal horn synapses by tissue injury
  • M. Baccei
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
  • 2010
Activity-dependent modulation of glutamatergic signaling in the developing rat dorsal horn by early tissue injury.
Neonatal tissue damage facilitates nociceptive synaptic input to the developing superficial dorsal horn via NGF-dependent mechanisms
Persistent changes in peripheral and spinal nociceptive processing after early tissue injury
Increased synaptic GluR1 subunits in the anterior cingulate cortex of rats with peripheral inflammation.
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