Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits

@article{Chatterton2002ExcitatoryGR,
  title={Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits},
  author={J. Chatterton and M. Awobuluyi and L. Premkumar and Hiroto Takahashi and M. Talantova and Y. Shin and Jiankun Cui and Shichun Tu and K. Sevarino and N. Nakanishi and Gang Tong and S. Lipton and Dongxian Zhang},
  journal={Nature},
  year={2002},
  volume={415},
  pages={793-798}
}
The N-methyl-d-aspartate subtype of glutamate receptor (NMDAR) serves critical functions in physiological and pathological processes in the central nervous system, including neuronal development, plasticity and neurodegeneration. Conventional heteromeric NMDARs composed of NR1 and NR2A–D subunits require dual agonists, glutamate and glycine, for activation. They are also highly permeable to Ca2+, and exhibit voltage-dependent inhibition by Mg2+. Coexpression of NR3A with NR1 and NR2 subunits… Expand
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