Excitatory effects of GABA in established brain networks

@article{Marty2005ExcitatoryEO,
  title={Excitatory effects of GABA in established brain networks},
  author={Alain Marty and Isabel Llano},
  journal={Trends in Neurosciences},
  year={2005},
  volume={28},
  pages={284-289}
}
  • A. Marty, I. Llano
  • Published 1 June 2005
  • Biology, Psychology
  • Trends in Neurosciences
Recent progress in GABAergic excitation from mature brain
  • L. Chung
  • Biology, Psychology
    Archives of pharmacal research
  • 2012
TLDR
In neural circuit activity, presumed GABAergic excitation was observed in basolateral amygdala during the study of a neuropeptide, cholecystokinin, and it may be implicated in epilepsy or anxiety in the adult brain.
Axonal GABAA receptors
TLDR
Whereas presynaptic GABAARs have long been considered inhibitory, the new studies in the mammalian brain mostly indicate an excitatory action, and axonal GABA ARs appear as potent neuronal modulators of the mammalian CNS.
Tonic modulation of GABA release by nicotinic acetylcholine receptors in layer V of the murine prefrontal cortex.
TLDR
Heteromeric nAChRs control GABA release presynaptically, whereas mixed nA ChRs regulate both excitation and inhibition of interneurons, the balance depending on the overall glutamatergic drive.
GABAergic Excitation in the Basolateral Amygdala
TLDR
Paired recordings from parvalbumin-positive interneurons in the basolateral amygdala show that single action potentials in a GABAergic interneuron can drive glutamatergic principal neurons to threshold, resulting in both feedforward and feedback excitation.
GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations.
TLDR
It is suggested that an evolutionary preserved role for excitatory GABA in immature cells provides an important mechanism in the formation of synapses and activity in neuronal networks.
Regulation of GABAA receptors by prolonged exposure to endogenous and exogenous ligands
Columnar distribution of activity dependent gabaergic depolarization in sensorimotor cortical neurons
TLDR
These results demonstrate that the well-known inhibitory transmitter GABA rapidly switches from hyperpolarization to depolarization upon synaptic activity in adult somatosensory cortical neurons.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 31 REFERENCES
Is there more to gaba than synaptic inhibition?
TLDR
The unique features of the early-appearing GABA signalling systems might help to explain how GABA acts as a developmental signal in the immature brain.
Excitatory actions of gaba during development: the nature of the nurture
TLDR
This work proposes that GABA becomes inhibitory by the delayed expression of a chloride exporter, leading to a negative shift in the reversal potential for choride ions, and provides a solution to the problem of how to excite developing neurons to promote growth and synapse formation.
GABA-dependent firing of glutamate-evoked action potentials at AMPA/kainate receptors in developing hypothalamic neurons.
TLDR
Results obtained in the presence of 2-amino-5-phosphonopentanoic acid indicate that GABA can facilitate glutamate responses independent of relief of the Mg2+ block of the N-methyl-D-aspartate (NMDA) receptor.
Coexistence of Excitatory and Inhibitory GABA Synapses in the Cerebellar Interneuron Network
TLDR
It is suggested that the coexistence of excitatory and inhibitory GABA synapses could either buffer the mean firing rate of the interneuron network or introduce different types of correlation between neighboring interneurons, or both.
On the Origin of Interictal Activity in Human Temporal Lobe Epilepsy in Vitro
TLDR
A spontaneous, rhythmic activity initiated in the subiculum of slices from patients with temporal lobe epilepsy was described, similar to interictal discharges of patient electroencephalograms.
Use-dependent shift from inhibitory to excitatory GABAA receptor action in SP-O interneurons in the rat hippocampal CA3 area.
TLDR
Results here implicate the rapid activity-dependent degradation of hyperpolarizing IPSPs in SP-O interneurons in setting the temporal limits for a given interneuron to participate in beta-gamma oscillations synchronized by GABAergic synapses, implying that mutual GABAergic excitation provided by interneURons may be an integral part in the function of neuronal networks.
Synaptically activated Cl- accumulation responsible for depolarizing GABAergic responses in mature hippocampal neurons.
TLDR
It is shown that the amplitude of synaptically induced depolarizing response was correlated with intracellular Cl- accumulation in the soma of mature hippocampal CA1 pyramidal cells, by using whole cell patch-clamp recording and Cl- imaging technique with a Cl- indicator 6-methoxy-N-ethylquinolinium iodide (MEQ).
Mixed excitatory and inhibitory GABA‐mediated transmission in chick cochlear nucleus
TLDR
Data indicate that IPSPs with reversal potentials positive to spike threshold may have dual functions, depending on the context of their activation, and that repetitive activation of the GABAergic axons reduced the probability of spiking in response to simultaneous stimulation of excitatory axons.
...
1
2
3
4
...