Excitatory effects of GABA in established brain networks

@article{Marty2005ExcitatoryEO,
  title={Excitatory effects of GABA in established brain networks},
  author={Alain Marty and Isabel Llano},
  journal={Trends in Neurosciences},
  year={2005},
  volume={28},
  pages={284-289}
}
  • A. Marty, I. Llano
  • Published 1 June 2005
  • Biology, Psychology
  • Trends in Neurosciences
View on Elsevier
doi.org
129 Citations
Highly Influential Citations
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129 Citations

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References

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TLDR
The unique features of the early-appearing GABA signalling systems might help to explain how GABA acts as a developmental signal in the immature brain.
Excitatory actions of gaba during development: the nature of the nurture
TLDR
This work proposes that GABA becomes inhibitory by the delayed expression of a chloride exporter, leading to a negative shift in the reversal potential for choride ions, and provides a solution to the problem of how to excite developing neurons to promote growth and synapse formation.
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TLDR
Results obtained in the presence of 2-amino-5-phosphonopentanoic acid indicate that GABA can facilitate glutamate responses independent of relief of the Mg2+ block of the N-methyl-D-aspartate (NMDA) receptor.
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It is suggested that the coexistence of excitatory and inhibitory GABA synapses could either buffer the mean firing rate of the interneuron network or introduce different types of correlation between neighboring interneurons, or both.
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A spontaneous, rhythmic activity initiated in the subiculum of slices from patients with temporal lobe epilepsy was described, similar to interictal discharges of patient electroencephalograms.
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TLDR
Results here implicate the rapid activity-dependent degradation of hyperpolarizing IPSPs in SP-O interneurons in setting the temporal limits for a given interneuron to participate in beta-gamma oscillations synchronized by GABAergic synapses, implying that mutual GABAergic excitation provided by interneURons may be an integral part in the function of neuronal networks.
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TLDR
It is shown that the amplitude of synaptically induced depolarizing response was correlated with intracellular Cl- accumulation in the soma of mature hippocampal CA1 pyramidal cells, by using whole cell patch-clamp recording and Cl- imaging technique with a Cl- indicator 6-methoxy-N-ethylquinolinium iodide (MEQ).
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