Excitatory and inhibitory effects of tricaine (MS-222) on fictive breathing in isolated bullfrog brain stem.

Abstract

This study examined the direct effects of tricaine methanesulfonate (MS-222), a sodium-channel blocking local anesthetic, on respiratory motor output using an in vitro brain stem preparation of adult North American bullfrogs (Rana catesbeiana). Bullfrogs were anesthetized with halothane, and the brain stem was removed and superfused with artificial… (More)

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