Excitatory and inhibitory actions of isoflurane on the cholinergic ascending arousal system of the rat.

@article{Dong2006ExcitatoryAI,
  title={Excitatory and inhibitory actions of isoflurane on the cholinergic ascending arousal system of the rat.},
  author={Hai-long Dong and Satoru Fukuda and Eri Murata and Takashi Higuchi},
  journal={Anesthesiology},
  year={2006},
  volume={104 1},
  pages={
          122-33
        }
}
BACKGROUND The cholinergic arousal systems are known to critically regulate the state of consciousness. The aim of this study was to determine the effect of isoflurane on the inhibitory or excitatory neurotransmitters efflux in important nuclei within the cholinergic arousal system using in vivo intracerebral microdialysis. METHODS The efflux of glutamate, gamma-aminobutyric acid (GABA), or acetylcholine in the posterior hypothalamus (PH), the basal forebrain (BF), and the somatosensory… CONTINUE READING

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