Excitatory amino acids in cerebrospinal fluid of patients with acute head injuries.

@article{Zhang2001ExcitatoryAA,
  title={Excitatory amino acids in cerebrospinal fluid of patients with acute head injuries.},
  author={Hong Zhang and X Zhang and Ting-miu Zhang and Li-Chiu Chen},
  journal={Clinical chemistry},
  year={2001},
  volume={47 8},
  pages={
          1458-62
        }
}
BACKGROUND The excitatory amino acids (EAAs) glutamate (Glu) and aspartate (Asp) play a role in the pathogenesis of postischemic and posttraumatic brain insult. The changes of EAAs in cerebrospinal fluid (CSF) of patients with traumatic brain injury are incompletely understood. METHODS We used reversed-phase HPLC with precolumn derivatization with o-phthalaldehyde and fluorescence detection to measure Glu and Asp in CSF of 42 patients with acute head injury and 9 control adults without… CONTINUE READING

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